Santen Pharmaceutical Sante Hyalein S 5ml x 2 bottles

SantenSKU: 4987084302779

Sante Hyalein S

¥2,107 JPY

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Class 2 OTC drugs

selection: 5ml x 2 bottles

5ml x 2 bottles

Product variants

Sante Hyalein S

¥2,107 JPY

selection: 5ml x 2 bottles

5ml x 2 bottles

Class 2 OTC Drug Eye drops Santen Pharmaceutical

Sante Hialine® S

Developed by Santen Pharmaceutical, an ophthalmic drug specialist, through extensive tear research. With medical-grade sodium hyaluronate, it keeps eyes moist and healthy.

✦ Contains 0.1% purified sodium hyaluronate ✦ Same ingredient as medical use ✦ Usable while wearing Contact lenses ✦ Thick, gentle feel

For these people and situations

👁️

For those concerned about eye fatigue and blurriness For those who get eye fatigue easily from long hours of PC or smartphone use, or feel blurred vision.

💧

For those troubled by dry eyes or foreign body sensation For those whose eyes dry easily in dry environments or from heating/cooling air, or who feel a rolling or prickling sensation.

🔵

For Contact lens users Can be used while wearing soft, hard, or disposable Contact lenses (except colored Contact lenses).

🏥

For those who did not improve with over-the-counter eye drops A switch OTC drug that approaches "lack of moisture," one cause of eye symptoms.

Product overview

Sante Hialine® S is a switch OTC drug Eye drops developed by Santen Pharmaceutical, a specialist in ophthalmic drugs, through extensive tear research. It contains 0.1% purified sodium hyaluronate, the same ingredient and concentration as medical drugs. Its high water retention keeps moisture lasting long and improves moisture deficiency, one cause of eye fatigue, dryness, and blurriness. It can be used with all Contact lenses except colored ones and features a thick, gentle feel.

Product features

Same ingredient and concentration as medical use

Purified sodium hyaluronate 0.1%

Contains the same ingredient and concentration as the medical Eye drops "Hialine Eye drops." With high water retention (holding 6L of water per gram), moisture lasts long after application.

Binds to mucin and stays longer in the tear film

Tear stabilization mechanism

Sodium hyaluronate binds to mucin on the eye surface, making it less likely to wash away with blinking and stays longer in the tear film to stabilize tears.

Improves from the "cause" of moisture deficiency

Approaches the cause of eye symptoms

One cause of symptoms like eye fatigue, dryness, and blurriness is "lack of moisture (tear problems)." Hialine S addresses this cause and cares for the symptoms.

Gentle feeling even when used with Contact lenses

Contact-compatible and preservative-conscious design

Can be used while wearing all Contact lenses except colored ones. Its thick Liquid texture gently blends in, making it easy to incorporate into daily eye care.

💧 What is sodium hyaluronate?

Sodium hyaluronate, a natural body component, has a high water retention capacity, holding 6 liters of water per gram. When applied as Eye drops, it binds to mucin on the eye surface and stays longer in the tear film to maintain moisture.

Comparison items	Other moisturizing ingredients Hypromellose, chondroitin, etc.	Sodium hyaluronate
Water retention	○	○
Binding to mucin	✕ Does not bind	✦ Binds
Residue after blinking	Flows away with old tears and evaporates	Stays longer in the tear film, stabilizing tears
Moisture retention	Short duration	Lasts long

Other moisturizing ingredients (image)
Flows away and evaporates with blinking

Sodium hyaluronate (image)
Binds to mucin and stays longer in the tear film

👁️ What are the benefits of lasting moisture?

Continuous moisture improves eye fatigue, dryness, and blurriness, leading to healthy eyes. When eye moisture is insufficient, tears become unstable, causing various uncomfortable symptoms.

🔴 Insufficient eye moisture (unstable tears)

Becomes more susceptible to external stimuli,
Causes eye fatigue, dryness, and blurred vision.

🔵 Normal eye moisture (stable tears)

Tears cover the surface of the eye,
Acts like a protective barrier for the eyes.

⚠️ Main symptoms caused by lack of moisture

Dry eyes
Eye fatigue
Blurred vision
Discomfort when wearing Contact lenses
Feeling of a foreign body (a rolling or prickling sensation)

Active ingredient

Ingredient name	Content amount	Classification
Purified sodium hyaluronate	0.1%	Moisture retention and tear stabilization

Additives: Aminocaproic acid, sodium edetate hydrate, chlorhexidine gluconate solution, isotonic agent, pH adjuster

Indications and Effects

Eye dryness Foreign body sensation (feeling of something rolling or prickling) Eye fatigue Eye blurriness Discomfort when wearing soft Contact lenses Discomfort when wearing hard Contact lenses

*Used to relieve the following eye symptoms.

Usage and Dosage

Amount per application	Number of times to apply per day
1 drop	5 to 6 times

When using on children, use under the guidance and supervision of a guardian.
Do not let the tip of the container touch your eyes, eyelids, or eyelashes.
For Eye drops use only.
Do not use while wearing colored Contact lenses.

❓ Frequently Asked Questions

QCan I use it while wearing Contact lenses?

AYou can use it while wearing all Contact lenses except colored Contact lenses (soft, O2, hard, disposable).

QHow long until I feel the effects?

AIf symptoms do not improve after one week (roughly one bottle), consult a doctor, pharmacist, or registered seller. Also consult if using for more than two weeks even if symptoms improve.

QWhy is consultation necessary if using for more than two weeks?

ABecause other eye diseases might be missed. If continuing use, consult a doctor, pharmacist, or registered seller.

QI don’t know how to open the container.

AThe opening tip of Hyalain S Eye drops is sealed before opening. Before use, turn the cap to the right until it reaches the shoulder of the container to open a hole in the tip. Do not screw the cap back on until use.

🌱 Brand Story

Santen Pharmaceutical was founded in 1890 and has over 130 years of history as a specialist manufacturer of ophthalmic medicines. "Hyalain S" is a switched OTC version of the sodium hyaluronate formulation long used in medical settings as the prescription medicine "Hialain Eye drops." Backed by ophthalmology expertise and tear research, it supports eye moisture.

⚠️ Usage Precautions

Do not use if: you have had allergic reactions to any ingredients of this product / diagnosed with dry eye, Sjögren's syndrome, Stevens-Johnson syndrome, or corneal infection / sudden vision loss or severe eye pain.
If rash, redness, itching, congestion, eye swelling, pain, foreign body sensation, or other symptoms appear after use, stop immediately and consult a doctor, pharmacist, or registered seller.
If eye blurriness does not improve, or if there is no improvement after one week of use, stop using and consult a professional.
If you have been diagnosed with glaucoma, consult a doctor or pharmacist before use.
Follow the prescribed usage and dosage.
This product is a medicine. If you have any questions, please consult a pharmacist or registered seller.

📦 Storage Precautions

Store away from direct sunlight, high temperature, and humidity.
Keep out of reach of children.
Do not transfer to other containers.
Use cleanly after opening and avoid contamination.

Package insert

● Features
Hyalein S is eye drops effective for "eye fatigue," "dry eyes," and "blurred vision" caused by tear instability. When the surface of the eye's tear layer becomes uneven due to excessive use or dryness, vision becomes blurry and uncomfortable symptoms such as "eye fatigue" occur. The active ingredient sodium hyaluronate in Hyalein S has a high moisture retention function, moisturizing the eyes and improving uncomfortable symptoms such as "eye fatigue," "dry eyes," and "blurred vision."
■ Hyalein S can be used while wearing all contact lenses except colored contact lenses.
Soft, O2, hard, disposable
It can also be used by those not wearing contact lenses.
* Some eye drops cannot be used while wearing soft contact lenses, so please check the outer box and attached documents carefully.

【Class 2 OTC Drug】

● Efficacy/Effects
Relief of the following eye symptoms: dryness, foreign body sensation (feeling of something rolling or prickling), fatigue, blurred vision, discomfort when wearing soft or hard contact lenses.

＜Precautions related to Efficacy/Effects＞

● Dosage and Administration
Instill 1 drop at a time, 5 to 6 times a day.

＜Precautions related to Dosage and Administration＞
● Please observe the following precautions.
(1) When used for children, use under the guidance and supervision of a guardian.
(2) Do not let the tip of the container touch the eyes, eyelids, or eyelashes. (Contamination or clouding of the solution may occur due to eye discharge or bacteria.) Do not use if the solution is cloudy.
(3) For ophthalmic use only.
(4) Do not use while wearing colored contact lenses.

● Ingredients/Quantity
Purified sodium hyaluronate 0.1%

〔Additives〕
Aminocaproic acid, sodium edetate hydrate, chlorhexidine gluconate solution, isotonic agent, pH adjuster

＜Precautions related to Ingredients/Quantity＞

● Dosage Form
Eye drops (external use [ophthalmic and otorhinolaryngologic agent] - liquid)

● Precautions for Use
■Do not do (Contraindications)
(If not followed, current symptoms may worsen or side effects may occur more easily)
Do not use if you:
(1) Have had allergic reactions to this product or its ingredients
(2) Have been diagnosed with dry eye, Sjögren's syndrome, Stevens-Johnson syndrome, or corneal infection
(3) Have symptoms such as sudden vision loss or severe eye pain (there is a risk of worsening condition, so do not self-treat and consult a doctor)
■Consult
1. Consult a doctor or pharmacist before use if you:
(1) Are receiving medical treatment
(2) Have had allergic reactions to medications
(3) Have symptoms other than eye symptoms such as:
・Dry mouth, dry nasal cavity
・High fever, lip inflammation, sore throat, widespread rash or redness on the skin that persists or rapidly worsens
(4) Have been diagnosed with glaucoma
2. If the following symptoms appear after use, they may be side effects; stop use immediately and consult a doctor or pharmacist with this document.
［Affected area: Symptoms］
Skin: rash, redness, itching
Eyes: redness, itching, swelling, pain, irritation, foreign body sensation, eye discharge
3. Stop use and consult a doctor or pharmacist with this document if:
(1) Blurred vision does not improve
(2) Symptoms do not improve after about one week of use according to dosage (roughly one bottle) or if any abnormalities are felt (consult before using a second bottle)
4. Even if symptoms improve, consult a doctor or pharmacist if using for more than two weeks.

●Precautions for Storage and Handling
(1) Do not screw on the cap until ready to use.
(2) Store tightly closed in a cool place away from direct sunlight. To maintain product quality, do not leave in places that become hot such as inside a car or near heating appliances. Do not use if the container is deformed or the solution leaks or deteriorates due to exposure to high temperatures.
(3) Keep out of reach of children.
(4) Do not transfer to other containers. (This may cause misuse or quality changes.)
(5) Do not share with others.
(6) Do not use products past the expiration date. Even within the expiration date, use as soon as possible after opening.
(7) Depending on storage conditions, crystals of the ingredient may form white deposits around the dropper tip or inside the cap. In such cases, gently wipe with clean gauze before use.