Class 2 OTC DrugOphthalmic Medication
Sante Medical 12
For eye fatigue, blurred vision, and redness from heavy use of computers, smartphones, and more
✦ 12 active ingredients✦ Formula for eye fatigue✦ Contains vitamin B12✦ Contains ingredients that help relieve redness
For people like this · At times like this
💻
Those who look at screens for long periods
When your eyes feel strained and tired from using a computer or smartphone.
👁️
When focusing is difficult
When eye fatigue makes things hard to see or vision seems blurred.
🔴
Those concerned about redness of the white of the eye
When you want to help relieve conjunctival (scleral) redness.
✨
When itching or blurriness is a concern
For eye itchiness or blurriness such as when discharge is excessive.
Product Overview
Sante Medical 12 is an ophthalmic medication (Class 2 OTC drug) from Santen Pharmaceutical. Centered on vitamin B12 (cyanocobalamin) and neostigmine methyl sulfate, which work to improve eye fatigue, it combines 12 active ingredients—including sodium chondroitin sulfate and chlorpheniramine maleate—at concentrations considered the maximum within the approval standards. The formula addresses discomfort that can arise when eyes are heavily used, such as eye fatigue, conjunctival redness, blurriness, and itching. Please consult a pharmacist or registered seller before use.
Product Features
01
Core ingredients that act on eye fatigue
Vitamin B12
Formulated with vitamin B12 (cyanocobalamin) and neostigmine methyl sulfate. The formula approaches ciliary muscle function and focusing ability, with the aim of improving eye fatigue and related symptoms.
02
4 ingredients at the maximum concentration within approval standards
Maximum concentration
Vitamin B12, neostigmine methyl sulfate, sodium chondroitin sulfate, and chlorpheniramine maleate are included at the maximum concentrations within the manufacturing and marketing approval standards for general ophthalmic drugs.
03
A multi-faceted formula with 12 active ingredients
12 ingredients
Ingredients that help relieve redness, anti-inflammatory and antihistamine components, and vitamin and amino acid ingredients that support tissue metabolism are balanced to address various types of eye discomfort.
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Moisture and corneal protection
Sodium chondroitin sulfate helps protect the cornea and reduce tear evaporation to keep the eyes moisturized.
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Helps relieve redness
Tetrahydrozoline hydrochloride helps relieve redness of the conjunctiva (the white of the eye).
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Consideration for itchiness and inflammation
Chlorpheniramine maleate, epsilon-aminocaproic acid, dipotassium glycyrrhizinate, zinc sulfate hydrate, and other ingredients address symptoms related to itchiness and inflammation.
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While wearing hard contact lenses
Indications include discomfort while wearing hard contact lenses (for use while wearing soft contact lenses, follow the product precautions).
Indications
Eye fatigue
Conjunctival redness
Blurred vision (e.g., when eye discharge is excessive)
Eye itchiness
Prevention of eye disease (e.g., after swimming, when dust or sweat enters the eyes)
Blepharitis (sore eyelids)
Ophthalmia due to ultraviolet or other light (e.g., snow blindness)
Discomfort while wearing hard contact lenses
Dosage and Administration
| Age |
Dose per use |
Times per day |
| Adults, children, etc. (follow the directions) |
1–3 drops per use |
Instill 5–6 times daily |
Always follow the dosage and administration directions and do not use excessively. If symptoms do not improve or worsen, stop use and consult a physician, pharmacist, or registered seller. Regarding suitability for soft contact lens wear and use while lenses are in, follow the package insert and on-label precautions. When used by children, use under the guidance and supervision of a guardian.
⚠️ Precautions for Use
- Read the package insert carefully before use and follow the dosage, administration, and precautions.
- This product is a Class 2 OTC drug. Consult a pharmacist or registered seller before purchase and use.
- Do not use if you have previously experienced allergic symptoms to this product or any of its ingredients.
- When instilling, take care that the liquid does not touch the tip of the container to avoid contamination.
- If symptoms such as dermatitis, increased eye redness, itching, or swelling appear during use, stop use and consult a physician, pharmacist, or registered seller.
- If you have strong symptoms such as eye pain, intense itching, or visual abnormalities, do not continue use on your own judgment; seek medical care.
- Avoid prolonged, indiscriminate use.
- When using with other eye drops, leave an interval between applications; if anything is unclear, check with a professional.
- Because this product contains a vasoconstrictor such as tetrahydrozoline hydrochloride, consider that redness may be due to infection or a serious condition; seek medical care if symptoms persist.
- If you fall under “Consult a doctor” or “Do not do” in the package insert, be sure to consult a professional before use.
📦 Storage Precautions
- Store tightly closed in a cool place away from direct sunlight.
- Keep out of reach of children.
- Do not transfer to another container (this may cause misuse or a change in quality).
- Do not touch or soil the dropper tip.
- Do not use the product after the expiration date.
- To maintain quality, avoid storing in a car or in hot, humid places.
● Features
Contains the maximum concentration of active ingredients effective for severe eye fatigue※
It is said that we obtain much of our information through our eyes. In modern society, where information technology has advanced, environments that overuse the eyes have increased. In such environments, the eye's focusing adjustment function declines, making it easy to experience eye fatigue, a heavy, dull feeling deep in the eyes.
Sante Medical 12 is an eye fatigue improvement eye drop that thoughtfully combines 12 types of active ingredients in a well-balanced manner, including four ingredients such as vitamin B12 and neostigmine methyl sulfate, which are effective for improving eye fatigue, at their maximum concentrations※. It works on the focusing adjustment muscles and the parasympathetic nervous system to enhance the weakened focusing adjustment function, moisturizes dry eyes, and further nourishes the eyes to promote tissue metabolism function. It supports a "healthy and clear" life for those living in modern society who overuse their eyes.
※Maximum concentration according to the standards for approval of general ophthalmic drugs: vitamin B12, neostigmine methyl sulfate, chondroitin sulfate ester sodium, chlorpheniramine maleate
【Class 2 OTC Drug】
● Efficacy/Effects
Eye fatigue, conjunctival hyperemia, blurred vision (such as when there is a lot of eye discharge), eye itching, prevention of eye diseases (such as after swimming, or when dust or sweat gets into the eyes), blepharitis (eyelid inflammation), eye inflammation caused by ultraviolet or other rays (such as snow blindness), discomfort when wearing hard contact lenses
＜Precautions related to Efficacy/Effects＞
● Dosage and Administration
Instill 1 to 3 drops per dose, 5 to 6 times a day.
＜Precautions related to Dosage and Administration＞
● Please observe the following precautions.
(1) Excessive use may cause abnormal glare or paradoxically cause hyperemia.
(2) When used for children, use under the guidance and supervision of a guardian.
(3) Do not let the tip of the container touch the eyes, eyelids, or eyelashes (to prevent contamination or turbidity of the solution due to eye discharge or bacteria). Do not use if the solution is cloudy.
(4) Do not use while wearing soft contact lenses.
(5) For ophthalmic use only.
● Ingredients/Quantity
Cyanocobalamin 0.02%
Neostigmine methyl sulfate 0.005%
Chondroitin sulfate ester sodium 0.5%
Pyridoxine hydrochloride 0.05%
Panthenol 0.05%
L-aspartic acid potassium 0.5%
Aminoethyl sulfonic acid (taurine) 0.5%
Chlorpheniramine maleate 0.03%
Epsilon-aminocaproic acid 1%
Dipotassium glycyrrhizinate 0.1%
Zinc sulfate hydrate 0.05%
Tetrahydrozoline hydrochloride 0.03%
〔Additives〕
Edetate disodium hydrate, chlorobutanol, sodium hyaluronate, benzalkonium chloride, boric acid, d-borneol, l-menthol, isotonic agent, pH adjuster
＜Precautions related to Ingredients/Quantity＞
This product may sometimes cause a sweet taste in the mouth after instillation. This is due to dipotassium glycyrrhizinate, one of the ingredients, flowing through the tear duct into the mouth and is not due to any abnormality in quality.
● Dosage Form
Eye drops (external use [ophthalmic and otorhinolaryngologic agent] - liquid)
● Precautions for Use
■ Consult
1. Consult a doctor, pharmacist, or registered seller before use if you:
(1) Are receiving medical treatment from a doctor
(2) Have had allergic reactions to medicines
(3) Have any of the following symptoms:
Severe eye pain
(4) Have been diagnosed with:
Glaucoma
2. If any of the following symptoms appear after use, discontinue use immediately and consult a doctor, pharmacist, or registered seller with this document, as they may be side effects.
［Affected area: Symptoms］
Skin: rash, redness, itching
Eyes: hyperemia, itching, swelling, stinging pain
3. Discontinue use and consult a doctor, pharmacist, or registered seller with this document if:
(1) Blurred vision does not improve
(2) Symptoms do not improve after 5 to 6 days of use
●Precautions for Storage and Handling
(1) Store tightly closed in a cool place away from direct sunlight. To maintain product quality, do not leave it in places that become hot, such as inside a car or near heating appliances. Do not use if the container is deformed or the solution leaks or deteriorates due to being left in a hot place.
(2) Keep out of reach of children.
(3) Do not transfer to other containers.
(This may cause misuse or change the quality.)
(4) Do not share with others.
(5) Do not use products past the expiration date. Even within the expiration date, use as soon as possible after opening.
(6) Depending on storage conditions, crystals of ingredients may appear red around the dropper tip or inside the cap. In such cases, gently wipe with a clean gauze before use.
(7) The red color of this product is due to vitamin B12 (cyanocobalamin). If the solution spills during instillation and stains clothing, wash immediately with water.
