Class 2 OTC DrugEye Drops
Sante Medical Plus 12
Eye drops for hard-to-ignore eye strain and redness from computer work and other focused tasks
✦ 12 active ingredients✦ Focused on focus-adjustment function✦ Also addresses redness, itchiness, and inflammation
For people like this · Situations like these
💻
Those whose eyes feel heavy from screen work
When you feel eye strain after focused work on a computer, smartphone, or similar device.
👁️
Those bothered by redness or burning
When conjunctival redness, eye itchiness, or discomfort from irritation is a concern.
☀️
Those bothered by light or external irritants
For care after eye inflammation from ultraviolet or other light (such as snow blindness), or after dust or sweat gets in the eyes.
🥽
While wearing hard contact lenses
For those bothered by discomfort while wearing hard contact lenses.
Product Overview
Sante Medical Plus 12 is an eye drop from Santen Pharmaceutical, a Class 2 OTC drug used for eye strain, conjunctival redness, eye itchiness, and related symptoms. Its formula combines multiple active ingredients, including components related to focus-adjustment function, as well as support for blood circulation, corneal protection, tissue metabolism, and considerations for redness, itchiness, and inflammation. It is used as an option for those concerned about troublesome eye symptoms after screen work or other focused tasks. Before use, read the package insert carefully and consult a pharmacist or registered seller.
Product Features
01
Formulated with 12 active ingredients
Multi-ingredient formula
A formula that combines active ingredients from multiple angles, including focus adjustment, blood circulation, corneal protection and moisture retention, tissue metabolism, itchiness and redness, and inflammation control.
02
Focused on focus-adjustment function
Adjustment support
Formulated with neostigmine methylsulfate and vitamin B12, designed to act on the focus-adjustment function that is often linked to eye strain.
03
Also addresses redness, itchiness, and inflammation
Symptom care
Formulated with tetrahydrozoline hydrochloride, chlorpheniramine maleate, dipotassium glycyrrhizinate, and other ingredients to address symptoms involving redness, itchiness, and inflammation.
✦
Formulation focused on maximum concentrations under approval standards
As a product claim, it is noted that active ingredients are formulated at the maximum concentrations under the approval standards.
✦
Corneal protection and moisture-retention ingredients
Contains sodium chondroitin sulfate ester, intended for corneal protection and moisture retention.
✦
Ingredients that support tissue metabolism
Contains vitamin B6, potassium L-aspartate, taurine, and other ingredients.
✦
For discomfort while wearing hard contact lenses
Indications include discomfort while wearing hard contact lenses (follow the package insert regarding use while wearing soft lenses).
Indications
Eye strain
Conjunctival redness
Eye itchiness
Blepharitis (eyelid sores)
Prevention of eye disease (after swimming, when dust or sweat gets in the eyes, etc.)
Eye inflammation caused by ultraviolet or other light (such as snow blindness)
Eye inflammation
Discomfort while wearing hard contact lenses
Dosage and Administration
| Age |
Dose per use |
Times per day |
| Adults (15 years and older) |
1–3 drops per use |
Apply 5–6 times daily |
| Under 15 years |
Do not use |
— |
For ophthalmic use only. Follow the stated dosage and administration. While using, check the precautions in the package insert; if symptoms do not improve or you notice anything unusual, stop use and consult a doctor, pharmacist, or registered seller.
⚠️ Precautions for Use
- Read the package insert carefully before use.
- Do not use if under 15 years of age.
- The following people should consult a doctor, pharmacist, or registered seller before use: those under a doctor’s care; those who have had allergic symptoms caused by medicines or similar; those with the following symptom (severe eye pain); those diagnosed with the following condition (glaucoma).
- If the following symptoms appear after use, they may be side effects; stop use immediately and consult a doctor, pharmacist, or registered seller with the product (skin: rash/redness, itchiness / eyes: redness, itchiness, swelling, stinging pain).
- In the following cases, stop use and consult a doctor, pharmacist, or registered seller: if blurred vision does not improve; if symptoms do not improve after 5–6 days of use.
- Do not use while wearing soft contact lenses (follow the package insert).
- When applying, do not let the tip of the container touch the eye, eyelid, or eyelashes.
- Because this product contains tetrahydrozoline hydrochloride, avoid excessive or frequent use and follow the dosage and administration.
- When using with other eye drops, leave an interval between applications; if anything is unclear, check with a pharmacist or registered seller.
- Do not use products past their expiration date.
📦 Storage Precautions
- Store tightly capped in a cool place away from direct sunlight.
- Store out of reach of children.
- Do not transfer to another container (may cause misuse or quality changes).
- Do not leave in hot places such as a car dashboard (the container may deform, and the solution may leak or change in quality).
- To maintain quality, keep the cap firmly closed even when not in use.
● Features
Effective for severe eye fatigue caused by concentrated work
Contains the maximum concentration of active ingredients※1※2
Troublesome eye problems such as "my eyes feel strained" and "my eyes feel heavy and tired" may be caused by the ciliary muscles※3 inside the eyes becoming stiff and poor blood circulation in the eyes due to concentrated work on computers or prolonged use of smartphones.
Sante Medical Plus 12 contains six active ingredients※1 effective for improving eye fatigue, including vitamin B12 and neostigmine methyl sulfate, at the maximum concentration※2. It also contains natural vitamin E (d-alpha-tocopheryl acetate) to improve blood flow, vitamin B6, potassium L-aspartate, and taurine to activate eye tissue metabolism, totaling 12 active ingredients. This eye drop improves blood flow in the eyes and works on the ciliary muscles※3 and peripheral nerves to enhance weakened focusing function and effectively improve eye fatigue.
※1 Vitamin B12, neostigmine methyl sulfate, chondroitin sulfate ester sodium, chlorpheniramine maleate, tetrahydrozoline hydrochloride, dipotassium glycyrrhizinate
※2 Maximum concentration according to the standards for manufacturing and marketing approval of general ophthalmic drugs (the approval standards refer to the range of pharmaceuticals established by the Ministry of Health, Labour and Welfare to streamline approval procedures)
※3 Ciliary muscle
【Class 2 OTC Drug】
● Efficacy/Effects
Eye fatigue, conjunctival hyperemia, blurred vision (such as when there is a lot of eye discharge), eye itching, prevention of eye diseases (such as after swimming or when dust or sweat gets into the eyes), blepharitis (eyelid inflammation), eye inflammation caused by ultraviolet or other rays (such as snow blindness), discomfort when wearing hard contact lenses
＜Precautions related to Efficacy/Effects＞
● Dosage and Administration
Instill 1 to 3 drops per dose, 5 to 6 times a day.
＜Precautions related to Dosage and Administration＞
● Please observe the following precautions.
(1) Excessive use may cause abnormal glare or worsen hyperemia.
(2) When used by children, use under the guidance and supervision of a guardian.
(3) Do not let the tip of the container touch the eyes, eyelids, or eyelashes (to prevent contamination or turbidity of the solution due to eye discharge or bacteria). Do not use if the solution is cloudy.
(4) Do not use while wearing soft contact lenses.
(5) For ophthalmic use only.
● Ingredients/Quantity
d-alpha-Tocopheryl acetate 0.025%
Cyanocobalamin 0.02%
Neostigmine methyl sulfate 0.005%
Chondroitin sulfate ester sodium 0.5%
Pyridoxine hydrochloride 0.05%
Potassium L-aspartate 0.5%
Aminoethylsulfonic acid (taurine) 0.5%
Chlorpheniramine maleate 0.03%
Epsilon-aminocaproic acid 1%
Dipotassium glycyrrhizinate 0.25%
Zinc sulfate hydrate 0.05%
Tetrahydrozoline hydrochloride 0.05%
〔Additives〕
Edetate disodium hydrate, sodium hyaluronate, benzalkonium chloride, boric acid, polyoxyethylene hardened castor oil, polysorbate 80, dibutylhydroxytoluene (BHT), d-borneol, l-menthol, isotonic agent, pH adjuster
＜Precautions related to Ingredients/Quantity＞
This product may sometimes cause a sweet taste in the mouth after instillation. This is due to dipotassium glycyrrhizinate, one of the ingredients, flowing into the mouth through the tear duct and is not due to any abnormality in quality.
● Dosage Form
Eye drops (external use [ophthalmic and otorhinolaryngologic agent] - liquid)
● Precautions for Use
■ Consult
1. Consult a doctor, pharmacist, or registered seller before use if you:
(1) Are receiving medical treatment from a doctor
(2) Have had allergic reactions to medicines
(3) Have any of the following symptoms:
Severe eye pain
(4) Have been diagnosed with:
Glaucoma
2. If any of the following symptoms appear after use, discontinue use immediately and consult a doctor, pharmacist, or registered seller with this document, as they may be side effects.
［Affected area: Symptoms］
Skin: rash, redness, itching
Eyes: hyperemia, itching, swelling, stinging pain
3. Discontinue use and consult a doctor, pharmacist, or registered seller with this document if:
(1) Blurred vision does not improve
(2) Symptoms do not improve after 5 to 6 days of use
● Precautions for Storage and Handling
(1) Store tightly closed in a cool place away from direct sunlight. To maintain product quality, do not leave it in places that become hot, such as inside a car or near heating appliances. Do not use if the container is deformed or the solution leaks or deteriorates due to being left in a hot place.
(2) Keep out of reach of children.
(3) Do not transfer to other containers.
(This may cause misuse or change the quality.)
(4) Do not share with others.
(5) Do not use products past the expiration date. Even within the expiration date, use as soon as possible after opening.
(6) Depending on storage conditions, crystals of ingredients may appear red around the dropper tip or inside the cap. In such cases, gently wipe with clean gauze before use.
(7) The red color of this product is due to vitamin B12 (cyanocobalamin). If the solution spills during instillation and stains clothing, wash immediately with water.
