Package insert

● Features
Effective for severe eye fatigue caused by concentrated work
Contains the maximum concentration of active ingredients※1※2
Troublesome eye problems such as "my eyes feel strained" and "my eyes feel heavy and tired" may be caused by the ciliary muscles※3 inside the eyes becoming stiff and poor blood circulation in the eyes due to concentrated work on computers or prolonged use of smartphones.
Sante Medical Plus 12 contains six active ingredients※1 effective for improving eye fatigue, including vitamin B12 and neostigmine methyl sulfate, at the maximum concentration※2. It also contains natural vitamin E (d-alpha-tocopheryl acetate) to improve blood flow, vitamin B6, potassium L-aspartate, and taurine to activate eye tissue metabolism, totaling 12 active ingredients. This eye drop improves blood flow in the eyes and works on the ciliary muscles※3 and peripheral nerves to enhance weakened focusing function and effectively improve eye fatigue.
※1 Vitamin B12, neostigmine methyl sulfate, chondroitin sulfate ester sodium, chlorpheniramine maleate, tetrahydrozoline hydrochloride, dipotassium glycyrrhizinate
※2 Maximum concentration according to the standards for manufacturing and marketing approval of general ophthalmic drugs (the approval standards refer to the range of pharmaceuticals established by the Ministry of Health, Labour and Welfare to streamline approval procedures)
※3 Ciliary muscle

【Class 2 OTC Drug】

● Efficacy/Effects
Eye fatigue, conjunctival hyperemia, blurred vision (such as when there is a lot of eye discharge), eye itching, prevention of eye diseases (such as after swimming or when dust or sweat gets into the eyes), blepharitis (eyelid inflammation), eye inflammation caused by ultraviolet or other rays (such as snow blindness), discomfort when wearing hard contact lenses

<Precautions related to Efficacy/Effects>

● Dosage and Administration
Instill 1 to 3 drops per dose, 5 to 6 times a day.

<Precautions related to Dosage and Administration>
● Please observe the following precautions.
(1) Excessive use may cause abnormal glare or worsen hyperemia.
(2) When used by children, use under the guidance and supervision of a guardian.
(3) Do not let the tip of the container touch the eyes, eyelids, or eyelashes (to prevent contamination or turbidity of the solution due to eye discharge or bacteria). Do not use if the solution is cloudy.
(4) Do not use while wearing soft contact lenses.
(5) For ophthalmic use only.

● Ingredients/Quantity
d-alpha-Tocopheryl acetate 0.025%
Cyanocobalamin 0.02%
Neostigmine methyl sulfate 0.005%
Chondroitin sulfate ester sodium 0.5%
Pyridoxine hydrochloride 0.05%
Potassium L-aspartate 0.5%
Aminoethylsulfonic acid (taurine) 0.5%
Chlorpheniramine maleate 0.03%
Epsilon-aminocaproic acid 1%
Dipotassium glycyrrhizinate 0.25%
Zinc sulfate hydrate 0.05%
Tetrahydrozoline hydrochloride 0.05%

〔Additives〕
Edetate disodium hydrate, sodium hyaluronate, benzalkonium chloride, boric acid, polyoxyethylene hardened castor oil, polysorbate 80, dibutylhydroxytoluene (BHT), d-borneol, l-menthol, isotonic agent, pH adjuster

<Precautions related to Ingredients/Quantity>
This product may sometimes cause a sweet taste in the mouth after instillation. This is due to dipotassium glycyrrhizinate, one of the ingredients, flowing into the mouth through the tear duct and is not due to any abnormality in quality.

● Dosage Form
Eye drops (external use [ophthalmic and otorhinolaryngologic agent] - liquid)

● Precautions for Use
■ Consult
1. Consult a doctor, pharmacist, or registered seller before use if you:
(1) Are receiving medical treatment from a doctor
(2) Have had allergic reactions to medicines
(3) Have any of the following symptoms:
Severe eye pain
(4) Have been diagnosed with:
Glaucoma
2. If any of the following symptoms appear after use, discontinue use immediately and consult a doctor, pharmacist, or registered seller with this document, as they may be side effects.
[Affected area: Symptoms]
Skin: rash, redness, itching
Eyes: hyperemia, itching, swelling, stinging pain
3. Discontinue use and consult a doctor, pharmacist, or registered seller with this document if:
(1) Blurred vision does not improve
(2) Symptoms do not improve after 5 to 6 days of use

● Precautions for Storage and Handling
(1) Store tightly closed in a cool place away from direct sunlight. To maintain product quality, do not leave it in places that become hot, such as inside a car or near heating appliances. Do not use if the container is deformed or the solution leaks or deteriorates due to being left in a hot place.
(2) Keep out of reach of children.
(3) Do not transfer to other containers.
(This may cause misuse or change the quality.)
(4) Do not share with others.
(5) Do not use products past the expiration date. Even within the expiration date, use as soon as possible after opening.
(6) Depending on storage conditions, crystals of ingredients may appear red around the dropper tip or inside the cap. In such cases, gently wipe with clean gauze before use.
(7) The red color of this product is due to vitamin B12 (cyanocobalamin). If the solution spills during instillation and stains clothing, wash immediately with water.