With One L
Zeria Pharmaceutical Co., Ltd. / Plant-based constipation medicine (Granule Stick)
Contains dietary fiber, herbal medicine sennosides, and spore-forming lactic acid bacteria that survive to the intestines.
For painful bloating constipation and recurring constipation — a plant-based formula that improves the intestinal environment.
For painful bloating constipation and recurring constipation — a plant-based formula that improves the intestinal environment.
Yogurt-flavored smooth Granules
Portable Stick packaging
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The "four powers" of plant-derived ingredients + lactic acid bacteria
With One L combines the plant-based double power of "swelling dietary fiber" and "pushing herbal medicine" with "spore-forming lactic acid bacteria that reach the intestines" and "nicotinamide that helps lactic acid bacteria proliferate" in a four-ingredient formula. It addresses abdominal bloating and recurring constipation by improving the intestinal environment.
💧 Swelling dietary fiber
Plantago ovata seed husk powder
Dietary fiber derived from Plantago ovata seed husk. Absorbs water and swells in the intestines, increasing stool bulk and promoting peristalsis. Also helps absorb intestinal toxins.⚡ Herbal medicine that pushes out stool
Sennosides
Herbal medicine derived from senna. It does not act on the small intestine but selectively stimulates only the large intestine to promote peristalsis. It activates weakened intestines.🦠 Lactic acid bacteria that reach the intestines
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Spore-forming lactic acid bacteria
Spore formation makes it resistant to heat and acid, reaching the intestines alive. It proliferates in the intestines, suppresses putrefactive bacteria growth, and improves the intestinal environment.
(Image) Dietary fiber swells in the intestines to increase stool bulk while lactic acid bacteria improve the intestinal environment and support elimination
🥛 Yogurt-flavored smooth Granules with adjustable dosage
Each granule swells in the intestines to increase stool bulk while lactic acid bacteria improve constipation from within. The smooth Granules type allows dosage adjustment according to your bowel movements, and Stick packaging makes it easy to take on the go. Yogurt-flavored and easy to take, designed for daily use.
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What are spore-forming lactic acid bacteria? — The secret to surviving to the intestines
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Spore formation makes it resistant to heat and acid
Typical lactic acid bacteria are easily killed by stomach acid and heat, but spore-forming lactic acid bacteria have spores that provide high resistance to stomach acid, bile acids, and heat. As a result, they reach the intestines alive.
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Proliferates in the intestines and improves the environment
Spore-forming lactic acid bacteria that reach the intestines proliferate in the gut and suppress the growth of harmful bacteria like putrefactive bacteria. By creating a gut environment dominated by beneficial bacteria, it addresses the root causes of abdominal bloating and recurring constipation.
🔬 The relationship between constipation and intestinal bacteria
Hundreds of species and 100 trillion intestinal bacteria live in the gut. These bacteria help intestinal peristalsis and regulate intestinal pH, essential for maintaining gut health. However, when the balance is disturbed, excessive gas is produced. Sitting in the same position for long periods or stress reducing gastrointestinal movement causes gas to remain in the intestines, leading to painful abdominal bloating. With One L contains dietary fiber plus lactic acid bacteria, which absorb harmful toxins, suppress putrefactive bacteria growth, and improve the intestinal environment.
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Five features of With One L
01
Dual intestinal care with dietary fiber + lactic acid bacteria
Dietary fiber increases stool bulk while spore-forming lactic acid bacteria improve the intestinal environment. Especially recommended for those concerned about abdominal bloating and recurring constipation.
02
Spore-forming lactic acid bacteria that survive to the intestines
Spore formation makes it resistant to stomach acid, bile acids, and heat, allowing it to reach the intestines alive, unlike typical lactic acid bacteria. It proliferates in the intestines and suppresses harmful bacteria growth.
03
Supports lactic acid bacteria with nicotinamide
Nicotinamide, a type of vitamin B3, acts as a growth factor for lactic acid bacteria, helping their proliferation and enhancing their activity in the intestines.
04
Gentle formula that rarely causes stomach pain
Gentle action based on plant-derived ingredients that rarely cause stomach pain and are unlikely to cause dependence. Designed for easy continued use even for recurring constipation.
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Yogurt-flavored, easy-to-take Granules
Easy-to-take yogurt-flavored smooth Granules for daily use. Convenient Stick packaging for portability, suitable for ages 3 and up with age-specific dosages.
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Indications and effects
Constipation Relief of abdominal bloating Abnormal intestinal fermentation Relief of rough skin Relief of acne Relief of heavy head Relief of hot flashes Improvement of loss of appetite Relief of hemorrhoids
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Ingredients and content (daily dose 4.8g, 3 packets)
| Ingredient name | Content | Role and action |
|---|---|---|
| Plantago ovata seed husk powder | 3,000 mg | Water-soluble dietary fiber. Swells in the intestines to increase stool bulk and promote peristalsis. |
| Sennosides (As sennosides A and B, 48 mg) |
123.08 mg | Herbal medicine derived from senna. Selectively stimulates only the large intestine to promote peristalsis. |
| Spore-forming lactic acid bacteria | 130 mg | Spore formation makes it resistant to stomach acid and heat, allowing it to reach the intestines alive. It suppresses the growth of putrefactive bacteria and improves the intestinal environment. |
| Nicotinamide | 5 mg | A type of vitamin B3. Acts as a growth factor to help the proliferation of spore-forming lactic acid bacteria in the intestines. |
* Other With One series (New With One, New With One α) have a daily dose of 3.6g (3 packets), but With One L has a daily dose of 4.8g (3 packets), with a different amount per packet.
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Usage and dosage
| Age | Single dose | Timing of intake |
|---|---|---|
| Adults (15 years and older) | 3/4 to 1 packet | 1 to 3 times a day, after meals |
| 11 years old to under 15 years old | 1/2 to 2/3 packet | 1 to 3 times a day, after meals |
| 3 years old to under 11 years old | 1/4 to 1/3 packet | 1 to 3 times a day, after meals |
| Under 3 years old | Do not take | |
💡 Taking Advice: Take without chewing with a full glass (about 180mL) of water or lukewarm water.
Always start with the minimum amount for the first time and gradually increase or decrease while monitoring bowel condition.
When children take it, always do so under the guidance and supervision of a guardian.
Always start with the minimum amount for the first time and gradually increase or decrease while monitoring bowel condition.
When children take it, always do so under the guidance and supervision of a guardian.
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Steps for taking
1
Take out the Stick
Open the Stick packaging and check the amount according to age and condition. Start with the minimum amount (3/4 packet for adults) for the first time.
2
Take with a full glass (about 180mL) of water
Take without chewing with water or lukewarm water. Since dietary fiber absorbs water and swells, sufficient fluid intake is key to effectiveness. Insufficient water may cause swelling in the esophagus or stomach.
3
Take after meals (1 to 3 times a day)
Take after meals. To help lactic acid bacteria settle, it is recommended to take it daily as much as possible.
4
Optimize dosage while monitoring bowel condition
Check your daily bowel condition and gradually increase or decrease the amount to find the optimal dose. Overdose may cause diarrhea or abdominal pain.
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With One Series Comparison and selection
New With One
For first-time users of laxatives
🍫 Chocolate flavor
Dietary fiber + sennosides +
Cascara sagrada dried extract
Cascara sagrada dried extract
New With One α
Also for constipation-related skin troubles
🍑 Peach flavor
Dietary fiber + sennosides +
Sankirai extract (skin care)
Sankirai extract (skin care)
With One L ★ This product
For constipation with bloating
🥛 Yogurt flavor
Dietary fiber + sennosides +
Spore-forming lactic acid bacteria that reach the intestines
Spore-forming lactic acid bacteria that reach the intestines
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Frequently Asked Questions
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What is the difference from other With One series?With One L's biggest feature is the added "spore-forming lactic acid bacteria that reach the intestines" and "nicotinamide that helps lactic acid bacteria proliferation." For painful constipation with bloating or recurring constipation, L is recommended to improve the intestinal environment. For first-time users, choose New With One; for those concerned about skin troubles, choose New With One α.
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What is the difference between spore-forming lactic acid bacteria and regular lactic acid bacteria?General lactic acid bacteria tend to die before reaching the intestines due to stomach acid, bile acids, and heat, but spore-forming lactic acid bacteria form spores, making them resistant to heat and acid, allowing them to reach the intestines alive. After reaching the intestines, they proliferate and suppress the growth of harmful bacteria like putrefactive bacteria, improving the intestinal environment.
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Why is the daily amount different from other With One series?With One L contains lactic acid bacteria and nicotinamide, so the daily amount is 4.8g (3 packets), which is more per packet than other series (3.6g). The amounts of dietary fiber and sennosides are equivalent.
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Why is it necessary to drink plenty of water?The main ingredient, Plantago ovata seed husk powder, is a dietary fiber that absorbs water and swells. Taking it with a full glass (about 180mL) of water allows it to swell properly in the intestines and be effective. Insufficient water may cause it to swell in the esophagus or stomach.
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From what age can it be used?It can be taken from age 3 and up. When children take it, always do so under the guidance and supervision of a guardian. Do not give to children under 3 years old.
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Can it be used during breastfeeding?If you are breastfeeding, either do not take this medicine or avoid breastfeeding while taking it. For details, consult a pharmacist or registered seller.
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Precautions for Use and Storage
⚠ Important Precautions for Use
- This is a Designated Class 2 OTC Drug. Consult a pharmacist or registered seller before use.
- Do not give to infants under 3 years old.
- Always take with a full glass (about 180mL) of water or lukewarm water. Taking without enough fluid is dangerous.
- If you are breastfeeding, either do not take this medicine or avoid breastfeeding while taking it.
- If you are pregnant or may be pregnant, consult a doctor or pharmacist before taking.
- If you have severe headache, nausea, or vomiting, consult a doctor or pharmacist before taking.
- If symptoms do not improve or worsen, stop taking the medicine and consult a doctor or pharmacist.
- Store in a cool, dry place away from direct sunlight and out of reach of children.
- Do not take products past their expiration date.
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With One Brand Story
The plant-based laxative "With One" is a brand born with the concept of addressing women's true feelings and concerns for natural-like bowel movements.
- 1955 Founded as Zeria Yakusou Research Institute in Chuo-ku, Tokyo.
- 1970 Company name changed to Zeria Pharmaceutical Co., Ltd.
- November 1987 Plant-based laxative With One launched — born as Japan's first full-fledged plant-based laxative.
- 2000 Listed on the First Section of the Tokyo Stock Exchange (now Prime Market).
- January 2012 Improved formula versions New With One and New With One α released. Evolved into a series selectable by specific concerns.
- ~Present With the addition of With One L, it has become a representative brand of Japanese plant-based laxatives, now covering intestinal environment care as a series.
⚕ This medicine should be used after consulting a pharmacist or registered seller and carefully reading the "Precautions for Use."