







Smile 40 Premium DX
Eye drops with 10 active ingredients that treat eye fatigue and blurred vision caused by age and strain from the cornea
For these people and situations
Product overview
Smile 40 Premium DX is a core product in Lion Corporation’s Smile DX series. It contains the maximum amount within standards (50,000 units) of “adsorptive Vitamin A (retinyl palmitate),” which supports visual function recovery by penetrating damaged corneal cells, retaining tears, and supporting corneal repair. Ten active ingredients including Vitamin E, B6, Taurine, and L-aspartic acid potassium salt provide multifaceted care for eye fatigue, inflammation, focus adjustment, redness, and itching.
No preservatives (such as benzalkonium chloride) are added; preservative effect is ensured by Lion’s unique technology (Manufacturing patent No. 5084967). Cool type with refreshing sensation level 4, characterized by a refreshing instillation feeling. Please consult a doctor, pharmacist, or registered seller if you have any questions.
Product features
Maximum amount of adsorptive Vitamin A included
Retinyl palmitate 50,000 unitsContains the maximum amount within standards of “adsorptive Vitamin A” that directly acts on the cornea, retains tears, and promotes corneal repair. Approaches the cause of recurring eye fatigue from the cornea (Manufacturing patent No. 5084967).
Multifaceted care with 10 active ingredients
Vitamin A, E, B6, Taurine, and othersContains 10 active ingredients with effects including metabolism promotion, focus adjustment, corneal protection, anti-inflammatory and soothing, itch suppression, and redness relief. Cares for many symptoms related to eye fatigue with one bottle.
Preservative-free
Lion’s unique preservative effect technologyNo preservatives such as benzalkonium chloride are added; Lion’s unique technology ensures preservative effect. Expiration date and storage method are the same as eye drops containing preservatives.
Cool type with refreshing sensation level 4
Contains l-menthol and d-borneolRefreshing sensation level 4 for a cool feeling. Suitable for those seeking relief from eye fatigue and a refreshing sensation.
Active ingredients (per 100mL)
| Ingredient name | Content amount | Action classification |
|---|---|---|
| Retinyl palmitate (Vitamin A) | 50,000 units | Corneal repair |
| d-α-Tocopherol acetate (natural Vitamin E) | 0.045g | Metabolism promotion |
| Pyridoxine hydrochloride (Vitamin B6) | 0.01g | Metabolism promotion |
| Chondroitin sulfate ester sodium | 0.1g | Corneal protection |
| Taurine | 1g | Metabolism promotion |
| L-aspartic acid potassium salt | 0.8g | Metabolism promotion |
| Neostigmine methyl sulfate | 0.005g | Focus adjustment |
| Chlorpheniramine maleate | 0.03g | Itch suppression |
| Epsilon-aminocaproic acid | 1g | Anti-inflammatory and soothing |
| Tetrahydrozoline hydrochloride | 0.05g | Redness relief |
Efficacy and effects
Dosage and administration
| Amount per application | Number of times to apply per day |
|---|---|
| 1 to 3 drops | 3 to 6 times |
・When used by children, use under the guidance and supervision of a guardian.
・Do not let the tip of the container touch your eyes, eyelids, or eyelashes.
・Do not use while wearing soft contact lenses.
・Use only as eye drops.
Smile DX Series Comparison
| Comparison items | 【Smile 40 Premium DX】 |
Smile 40 MediClear DX |
Smile The Medical A DX |
Smile The Medical A DX Contact |
|---|---|---|---|---|
| Classification | Class 2 OTC Drug | Class 2 OTC Drug | Class 3 OTC Drug | Class 3 OTC Drug |
| Main target symptoms | Eye fatigue, blurriness, redness, itching | Itching, redness, blurriness | Dryness, fatigue from overuse, blurriness | Dryness, fatigue from overuse, blurriness |
| Vitamin A content | 50,000 units (maximum amount) | 10,000 units | 50,000 units (maximum amount) | 50,000 units (maximum amount) |
| Number of active ingredients | 10 types | 7 types | 3 types | 4 types |
| Anti-inflammatory ingredient | Epsilon-aminocaproic acid | Berberine chloride hydrate + dipotassium glycyrrhizinate (double herbal formulation) | None | None |
| Redness relief ingredient | Tetrahydrozoline hydrochloride | None | None | None |
| Itching suppression ingredient | Chlorpheniramine maleate | Chlorpheniramine maleate | None | None |
| Corneal protective ingredient | Chondroitin sulfate ester sodium | None | None | Chondroitin sulfate ester sodium |
| Cooling sensation | Level 4 (Cool) | Level 4 (Cool) | Level 0 (Mild) | Level 0 (Mild) |
| Use while wearing contacts | Compatible with hard lenses only | Compatible with hard lenses only | Not compatible (naked eye and hard lenses only) | Compatible with all contacts (except colored CL) |
| Preservative | Additive-free | Additive-free | Additive-free | Additive-free |
| For these users | For those concerned about eye fatigue plus itching and redness | For those particularly concerned about itching and redness | For those concerned about dryness-related fatigue with naked eyes | For those who want to use eye drops while wearing contacts |
🌱 Brand Story
Lion Corporation's "Smile" is a long-trusted ophthalmic drug brand in Japan. We have established the "Corneal Research Institute" and continue unique research on the cornea, the key to eye health. The DX series is based on the concept of "healing from the cornea," achieving a unique formula (patented manufacturing and method) that enhances vitamin A penetration into the cornea. Additionally, Lion's unique technology provides high preservative effects without adding preservatives, pursuing a gentle formula for the eyes.
- Consult a doctor, pharmacist, or registered seller before use: Those receiving medical treatment. Those who have had allergic reactions to medicines. Those with severe eye pain. Those diagnosed with glaucoma.
- If symptoms such as rash, redness, itching/redness, itching, swelling, or stinging pain appear after use, stop using immediately and consult a doctor, pharmacist, or registered seller.
- If eye blurriness does not improve, or if symptoms do not improve after 5 to 6 days of use, discontinue use and consult a doctor, pharmacist, or registered seller.
- Do not use while wearing soft contact lenses.
- Excessive use may cause abnormal glare or even lead to redness.
- Do not let the tip of the container touch your eyes, eyelids, or eyelashes (this may cause contamination or foreign matter intrusion). Do not use if the solution is cloudy.
- Avoid direct sunlight and store in a cool place as much as possible.
- Keep out of reach of children.
- Do not transfer to other containers (this may cause misuse or change the quality).
- Do not use the product after the expiration date.
- Please use as soon as possible after opening.





















































































