Fluid buildup in the knee
What causes it?
Why does "fluid build up in the knee"? Intense exercise like sports, injuries, and aging cause worn cartilage (①), which leads to joint inflammation. The inflammation stimulates synovial cells (②), causing excessive production of “synovial fluid (③),” the lubricant of the knee joint, resulting in fluid buildup in the knee.
*Our company survey FA (February 2025) N=85 (men and women aged 20-69 who have experienced fluid buildup in the knee within the past year)
*Voices matching our company’s planning intent are excerpted and edited for introduction
Mizunain's
Effects and Mechanism
Mizunain is a Kampo formula called "Eppikajutsubuto," made from 7 types of herbal medicines, which calms inflammation caused by fluid buildup in the knee, reduces the fluid accumulated in the knee, and improves painful and distressing knee symptoms.
Knee
Calming inflammation and reducing fluidBy
Recurring"Pain and difficulty moving"
Effective for!
Mizunain Product Information
- Ingredients and Quantity
- Daily amount (12 Tablets): 2.6g of Eppikajutsubuto extract
Ephedra, Gypsum, Atractylodes, Aconite powder, Ginger, Licorice, Jujube
Contains anhydrous silica, silica Al, CMC-Ca, lactose, and magnesium stearate as additives
- Indications and Effects
- For those with moderate or higher physical strength who experience coldness, swelling, thirst, sweating, and sometimes reduced urine output, the following symptoms: swelling, joint swelling and pain, muscle pain, eczema/dermatitis, bedwetting, eye itching and pain
- Dosage and Administration
- Adults (15 years and older): Take 4 Tablets per dose, 3 times a day before or between meals with water or hot water. (Do not take if under 15 years old)
● Features
〇 This is the Kampo formula "Eppikajutsuto," made from 7 types of herbal medicines.
〇 It suppresses swelling in joints caused by fluid accumulation and relieves pain.
〇 Comes in an easy-to-carry pouch type.
【Class 2 OTC Drug】
● Efficacy/Effects
For individuals with moderate or higher physical strength who experience coldness, swelling, thirst, sweating, and sometimes decreased urine output, the following symptoms: swelling, joint swelling and pain, muscle pain, eczema/dermatitis, nocturnal enuresis, eye itching and pain.
＜Precautions related to Efficacy/Effects＞
● Dosage and Administration
[Age: Dose per time: Number of doses per day]
Adults (15 years and older): 4 tablets: 3 times
Under 15 years: Do not take
＜Precautions related to Dosage and Administration＞
● Ingredients/Quantity
Eppikajutsuto extract 2.6g
Ephedra 3.0g
Gypsum 4.0g
Atractylodes 2.0g
Fossilized animal bone powder 0.5g
Ginger 0.5g
Licorice 1.0g
Jujube 1.5g
〔Additives〕
Anhydrous silica, aluminum silicate, CMC-Ca, lactose, magnesium stearate
＜Precautions related to Ingredients/Quantity＞
Since this product uses natural substances (herbal medicines), the color of the tablets may vary slightly.
● Dosage Form
Tablet (oral tablet)
● Precautions for Use
■ Consult
1. Before taking, consult a doctor, pharmacist, or registered seller if you:
(1) Are receiving medical treatment from a doctor
(2) Are pregnant or think you may be pregnant
(3) Are physically weak (declining physical strength or frail)
(4) Have a weak stomach or intestines
(5) Have strong flushing, a red face, and robust physical strength
(6) Tend to sweat excessively
(7) Are elderly
(8) Have had rash, redness, itching, etc., caused by medicines before
(9) Have symptoms such as swelling or difficulty urinating
(10) Have been diagnosed with high blood pressure, heart disease, kidney disease, or thyroid dysfunction
2. If any of the following symptoms appear after taking this medicine, stop taking it immediately and consult a doctor, pharmacist, or registered seller with the product pouch, as these may be side effects:
Affected area: Symptoms
Skin: Rash, redness, itching
Digestive system: Nausea, loss of appetite, stomach discomfort
Others: Palpitations, flushing, hot flashes, numbness of lips or tongue
Rarely, the following serious symptoms may occur. In such cases, seek medical attention immediately:
Name of symptom: Symptoms
Pseudoaldosteronism, myopathy: Weakness, numbness, stiffness or rigidity of limbs, accompanied by fatigue and muscle pain that gradually worsens
3. If symptoms do not improve after about one month of use, stop taking the medicine and consult a doctor, pharmacist, or registered seller with the product pouch.
4. If using for a long period, consult a doctor, pharmacist, or registered seller.
5. In rare cases, symptoms may worsen after taking this medicine. If this happens, stop taking it and consult a doctor, pharmacist, or registered seller with the product pouch.
● Precautions for Storage and Handling
(1) Store in a cool, dry place away from direct sunlight with the zipper firmly closed.
(2) Keep out of reach of children.
(3) Do not transfer to other containers (may cause misuse or quality changes).
(4) Do not handle this medicine with wet hands.
