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Home Sante Medical Guard & Repair
参天製薬 サンテ メディカル ガード&リペア 12ml
参天製薬 サンテ メディカル ガード EX 12ml
参天製薬 サンテ メディカル ガード&リペア 12ml
参天製薬 サンテ メディカル ガード EX 12ml
SantenSKU: 4987084320162

Sante Medical Guard & Repair

¥1,755 JPY /
Tax included. Shipping calculated at checkout.
Class 2 OTC drugs

Product name : Medical Guard EX
selection Guard & Repair 12ml (New)
参天製薬 サンテ メディカル ガード&リペア 12ml
Sante Medical Guard & Repair
¥1,755 JPY /
selection Guard & Repair 12ml (New)
 
 
New release Class 2 OTC Drug Santen Pharmaceutical 10 active ingredients 12mL

Sante Medical
Guard & Repair

Due to dryness and corneal damage
For stinging and eye inflammation*.
*Ocular inflammation caused by ultraviolet and other light rays (such as snow blindness)

🛡 Contains corneal repair & barrier function enhancing ingredients 💧 6 ingredients formulated at maximum concentration 👁 Contains chondroitin

For these situations

Eye strain caused by dryness or Contact lens wear

Due to dryness or Contact lens wear
For those whose eyes are under strain

Discomfort after removing Contact lenses

Discomfort after removing Contact lenses

Eyes feel dry and rough

Eyes feel dry and rough

Eye surface stings or prickles

Eye surface stings or prickles

*Discomfort when wearing hard Contact lenses
Frequently rubs eyes

Frequently rubs eyes

Exposed to ultraviolet rays

Exposed to ultraviolet rays

Product features

Repair of damaged tissue

Promotes repair of damaged tissue,
Suppresses inflammation (such as snow blindness)

Corneal protection and moisturizing

Protects and moisturizes the cornea
Improves eye fatigue caused by dryness and more

Tissue metabolism promotion

Promotes tissue metabolism
Improves eye fatigue

OVERVIEW Product Overview

Sante Medical Guard & Repair is an ophthalmic drug (Class 2 OTC Drug) newly released by Santen Pharmaceutical in November 2025. Modern eyes are subjected daily to damage on the corneal surface due to overuse, rubbing, Contact lens wear, ultraviolet rays, and more. If such corneal damage is left untreated, it can worsen eye inflammation or cause eye diseases.
This product contains zinc sulfate hydrate, a corneal repair & barrier function enhancing ingredient, and chondroitin sulfate ester sodium, a corneal protection and moisturizing ingredient, among 6 ingredients formulated at the maximum concentration within approval standards, totaling 10 active ingredients. It repairs and protects corneal damage, effectively addressing eye inflammation (such as snow blindness) and preventing eye diseases and other eye troubles.

INGREDIENTS Active ingredients, amounts, and functions

Ingredient name Amount Function
Zinc sulfate hydratemaximum concentrationcorneal repair 0.25% Promotes repair of damaged tissue and suppresses inflammation.
Chondroitin sulfate ester sodiummaximum concentration 0.5% Protects the cornea and provides moisture to the eyes by preventing tear evaporation.
Taurine 0.5% Activates tissue metabolism in the eyes.
Vitamin B6 (pyridoxine hydrochloride)maximum concentration 0.1% Activates tissue metabolism in the eyes.
Panthenol 0.05% Activates tissue metabolism in the eyes.
L-aspartic acid potassium salt 0.5% Enhances tissue respiration in the eyes.
Neostigmine methyl sulfatemaximum concentration 0.005% Improves focusing function, relieving eye fatigue and more.
Chlorpheniramine maleatemaximum concentration 0.03% Suppresses the action of histamine, reducing eye inflammation and itching.
Epsilon-Aminocaproic acid 1.0% Suppresses the production of substances that cause inflammation.
Tetrahydrozoline hydrochloridemaximum concentration 0.05% Suppresses redness of the conjunctiva (the white part of the eye).
Additives: Edetate disodium hydrate, chlorobutanol, geraniol, boric acid, sodium hyaluronate, polysorbate 80, d-borneol, l-menthol, isotonic agent, pH adjuster

*Maximum concentration = maximum concentration formulation based on the standards for general ophthalmic drug manufacturing and marketing approval (6 ingredients)

EFFICACY Indications and Effects

Eye inflammation caused by ultraviolet or other rays (snow blindness, etc.), blepharitis (eyelid inflammation), prevention of eye diseases (after swimming, when dust or sweat gets into the eyes, etc.), eye fatigue, eye itching, eye blurriness (when there is a lot of eye discharge), conjunctival redness, discomfort when wearing hard Contact lenses

DOSAGE Dosage and Administration

Instill the following amount 5 to 6 times a day.

Age Amount per instillation Number of times per day
Adults and children (7 years and older) 1 to 3 drops 5 to 6 times
Under 7 years old × Do not use —
Precautions related to dosage and administration
  • Strictly follow the dosage and administration instructions.
  • When used by children, use under the guidance and supervision of a guardian.
  • When instilling, avoid touching the tip of the container to eyelids, eyelashes, or eyes (to prevent contamination).
  • For ophthalmic use only.

COMPARISON Sante Medical Series Comparison Table

Comparison of 3 products: Sante Medical Plus 12, Guard & Repair, Active
Comparison items Medical
Guard & Repair
(This product)
Medical 12 Medical
Active
Main concerns & features Corneal damage repair, inflammation, and stinging Eye fatigue and redness Eye fatigue, blurriness, and dryness due to aging
Number of active ingredients 10 types ★ 12 types 9 types
Maximum concentration ingredient count ★ 6 ingredients 4 ingredients 5 ingredients
Zinc sulfate hydrate
(Corneal repair & barrier)
✔ 0.25% 0.05% -
Vitamin B12
(Ciliary muscle & eye fatigue)
- ✔ 0.02% -
Vitamin A
(Tear secretion & corneal protection)
- - ✔ 50,000 units
Vitamin E
(Blood flow improvement)
- - ✔ 0.05%
Neostigmine
(Focus adjustment)
✔ ✔ ✔
Chondroitin
(Moisturizing & corneal protection)
✔ ✔ ✔
Epsilon-Aminocaproic acid
(Anti-inflammatory)
✔ 1.0% ✔ 1.0% ✔ 1.0%
Glycyrrhizic acid
(Anti-inflammatory)
- ✔ 0.1% -
Redness relief ingredient
(Tetrahydrozoline)
✔ 0.05% 0.03% 0.01%
Panthenol
(Tissue metabolism)
✔ 0.05% ✔ 0.05% -
For people like this Eyes are easily damaged by Contact lenses, UV rays, and dryness. Want to focus on corneal repair. Eyes are overused with PC and smartphones. Want to thoroughly care for redness and eye fatigue. Concerned about dry eyes, blurriness, and fatigue due to aging.

* Ingredient content is based on the official Santen Pharmaceutical package inserts for each product. Please check the latest product labeling at the time of purchase.

CAUTION Precautions for Use / Storage Precautions

⚠️ Do Not Do
  • Do not use if you have had allergic reactions to this product or its ingredients.
  • Do not use on the following areas: around the eyes or inside the mouth
  • Do not use while wearing soft Contact lenses.
🩺 Consult
  • People receiving treatment from a doctor or dentist
  • People who have had allergic reactions to medicines
  • People with the following symptoms: severe eye pain
  • People diagnosed with: glaucoma
  • If allergic symptoms such as redness, itching, or swelling appear after instilling, stop use immediately and consult a doctor, pharmacist, or registered seller.
  • If eye blurriness does not improve, consult a doctor, pharmacist, or registered seller.
🏠 Storage Precautions
  • Store tightly closed in a cool place away from direct sunlight.
  • Keep out of reach of children.
  • Do not transfer to other containers (this may cause misuse or change the quality).
  • Do not use products past the expiration date.
  • Use within 3 months after opening as a guideline.
  • Close the cap immediately after instilling the eye drops.
* The content on this page is based on information published on the official Santen Pharmaceutical website and the package insert.
* For product details and the latest information, please be sure to check the package insert included with the product.
* "Corneal Repair & Barrier Function Improvement Ingredients": Eri Matsuura et al., Medicine and Pharmacy 82(5): P241, 2025
【Class 2 OTC Drug】Please read the "Precautions for Use" carefully before using this medicine.

● Features
For eye strain caused by dryness and inflammation: contains the maximum concentration※2 of active ingredients such as corneal repair※1 and protective components.
Modern people suffer daily damage to the cornea (the surface of the eye) due to overuse of the eyes, itching and rubbing, wearing contact lenses, ultraviolet rays, and more. If such corneal damage is left untreated, it can worsen eye inflammation or cause eye diseases.
Sante Medical Guard EX contains a well-balanced blend of 10 carefully selected active ingredients, including six components at maximum concentration※2 such as Flavin Adenine Dinucleotide Sodium (active vitamin B2), which promotes corneal tissue metabolism and repair, and Chondroitin Sulfate Ester Sodium, which moisturizes and protects the cornea. This eye drop repairs and protects corneal damage and is effective in preventing eye inflammation and eye diseases.
It cares for your delicate eyes and supports a "healthy and clear" life.
※1 Promotes corneal tissue metabolism and repair function
※2 Maximum concentration according to the standards for manufacturing and marketing approval of general ophthalmic drugs: Flavin Adenine Dinucleotide Sodium (active vitamin B2), Chondroitin Sulfate Ester Sodium, Vitamin B6, Neostigmine Methyl Sulfate, Chlorpheniramine Maleate, Dipotassium Glycyrrhizinate

【Class 2 OTC Drug】

●Efficacy/Effects
Eye inflammation caused by ultraviolet rays and other light (such as snow blindness), blepharitis (eyelid inflammation), prevention of eye diseases (after swimming, when dust or sweat gets into the eyes, etc.), eye fatigue, eye itching, blurred vision (such as when there is a lot of eye discharge), conjunctival hyperemia, discomfort when wearing hard contact lenses

<Precautions related to Efficacy/Effects>

●Dosage and Administration
Instill 1 to 3 drops per application, 5 to 6 times a day.

<Precautions related to Dosage and Administration>
●Please observe the following precautions.
(1) Excessive use may cause abnormal glare or worsen redness.
(2) When used by children, use under the guidance and supervision of a guardian.
(3) Do not let the tip of the container touch the eyes, eyelids, or eyelashes (to prevent contamination or turbidity of the solution due to eye discharge or bacteria). Do not use if the solution is cloudy.
(4) Do not use while wearing soft contact lenses.
(5) For ophthalmic use only.

●Ingredients/Quantity
Flavin Adenine Dinucleotide Sodium 0.05%
Chondroitin Sulfate Ester Sodium 0.5%
Aminoethylsulfonic Acid (Taurine) 0.5%
Pyridoxine Hydrochloride 0.1%
L-Aspartic Acid Potassium 0.5%
Neostigmine Methyl Sulfate 0.005%
Chlorpheniramine Maleate 0.03%
Epsilon-Aminocaproic Acid 1%
Dipotassium Glycyrrhizinate 0.25%
Tetrahydrozoline Hydrochloride 0.01%

〔Additives〕
Edetate Sodium Hydrate, Chlorobutanol, Geraniol, Dextran, Sodium Hyaluronate, Hydroxyethyl Cellulose, Benzalkonium Chloride Solution, Borax, Polysorbate 80, d-Borneol, l-Menthol, Isotonic Agent, pH Adjuster

<Precautions related to Ingredients/Quantity>
This product may sometimes cause a sweet taste in the mouth after instillation. This is due to dipotassium glycyrrhizinate, one of the ingredients, flowing into the mouth through the tear duct and is not due to any abnormality in quality.

●Dosage Form
Eye drops (external use [ophthalmic and otorhinolaryngologic agent] - liquid)

●Precautions for Use
■Consult
1. Consult a doctor, pharmacist, or registered seller before use if you:
(1) Are receiving medical treatment from a doctor
(2) Have had allergic reactions to medicines
(3) Have any of the following symptoms:
Severe eye pain
(4) Have been diagnosed with:
Glaucoma
2. If any of the following symptoms appear after use, stop using immediately and consult a doctor, pharmacist, or registered seller with this document, as they may be side effects.
[Affected area: Symptoms]
Skin: rash, redness, itching
Eyes: redness, itching, swelling, stinging pain
3. Stop use and consult a doctor, pharmacist, or registered seller with this document if:
(1) Blurred vision does not improve
(2) Symptoms do not improve after 5 to 6 days of use

●Precautions for Storage and Handling
(1) Store tightly closed in a cool place away from direct sunlight. To maintain product quality, do not leave in places that become hot such as inside a car or near heating appliances. Do not use if the container is deformed or the solution leaks or deteriorates due to exposure to high temperatures.
(2) Keep out of reach of children.
(3) Do not transfer to other containers. (This may cause misuse or change the quality.)
(4) Do not share with others.
(5) Do not use products past the expiration date. Even within the expiration date, use as soon as possible after opening.
(6) Depending on storage conditions, crystals of ingredients may form yellow deposits around the dropper tip or inside the cap. In such cases, gently wipe with a clean gauze before use.
(7) The yellow color of this product is due to Flavin Adenine Dinucleotide Sodium (active vitamin B2). If the solution spills during instillation and stains clothing, wash immediately with water.


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