
Designated Class 2 OTC Drug Plant-based laxative 🍑 Peach flavor Contains skin care ingredients Made in Japan
Shin With One α (Alpha) Peach flavor
Promotes natural-like bowel movements with dietary fiber + herbal medicine,
Contains skin care ingredient Sanki-Rai extract to simultaneously address constipation-related rough skin.
Contains skin care ingredient Sanki-Rai extract to simultaneously address constipation-related rough skin.
Shin With One α Peach flavor — 12 packets
Smooth granule Stick packaging
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Plant-derived double power of "swelling and pushing"
The With One series combines two plant-derived ingredients, "swelling dietary fiber" and "pushing herbal medicine," for natural-like bowel movements. It is a plant-based formula that is gentle on the stomach yet promotes strong bowel movements.
💧 Swelling dietary fiber

Plantago Ovata seed husk powder
Made from the seed husk of Indian Plantain. Absorbs water and swells in the intestines, increasing stool bulk and promoting intestinal peristalsis. It softens hardened stool moderately and helps expel harmful toxins in the intestines by adsorption.⚡ Pushing herbal medicine

Sennoside
Derived from the legume plant senna. It does not act on the small intestine but selectively stimulates only the large intestine to promote peristalsis. It activates weakened intestinal function and supports the power to push out stool.
(Image) Dietary fiber swells in the intestines, increasing stool bulk and supporting elimination
📦 Smooth granule Stick with adjustable dosage
Each granule swells in the intestines to increase stool bulk and support elimination. The smooth granule type allows dosage adjustment according to your bowel movements and comes in convenient Stick packaging. Peach flavor makes it easy to take, even when out.
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Six features of Shin With One α
01
Double formulation of dietary fiber + skin care ingredients
In addition to Plantago Ovata seed husk powder, it contains Sanki-Rai extract that relieves rough skin and pimples. It cares for both constipation and skin concerns simultaneously.
02
Detoxifying effect of Sanki-Rai extract
Sanki-Rai expels waste from the body through diuretic and detoxifying effects, addressing rough skin and pimples caused by constipation at the root.
03
Reliable effect with Sennoside
Sennoside derived from senna promotes peristalsis in the large intestine. The swelling power of dietary fiber and the pushing power of herbal medicine achieve a strong bowel movement.
04
Gentle even for first-time users
Formulated with plant-based ingredients that are gentle on the stomach. Designed to be easy to use even for first-time users of laxatives.
05
Peach flavor, easy-to-take granules
Smooth granules with peach flavor. Easy to continue daily with a pleasant taste, and the Stick packaging makes it convenient to take even when out or traveling.
06
Usable from 3 years old with age-specific dosages
Can be taken from 3 years old with age-specific dosages set (not for under 3 years old). Suitable for the whole family from children to adults.
📊 Our survey data (May 2019, n=511) shows a strong relationship between constipation and rough skin
63.8%
Percentage of people with constipation who also experience rough skin
Compared to those without constipation, 27.6 points higher results. It is believed that waste products and harmful gases in the intestines caused by constipation are reabsorbed into the bloodstream and circulate throughout the body, damaging skin cells and causing rough skin. Shin With One α improves constipation while also addressing this damage with skin care ingredients.
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Indications and effects
Constipation Relief of rough skin Relief of pimples Relief of heavy head Relief of hot flashes Improvement of loss of appetite Relief of abdominal bloating Abnormal intestinal fermentation Relief of hemorrhoids
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Ingredients and content (daily dose 3.6g, 3 packets)
| Ingredient name | Content amount | Role and action |
|---|---|---|
| Plantago Ovata seed husk powder | 3,000 mg | Water-soluble dietary fiber. Swells in the intestines to increase stool bulk and promote peristalsis. |
| Sennoside (48 mg as Sennoside A and B) |
123.08 mg | Herbal medicine derived from senna. Selectively stimulates the large intestine to promote peristalsis. |
| Sanki-Rai extract (Equivalent to 540 mg of Sanki-Rai) |
43.2 mg | Diuretic and detoxifying effects. Skin care ingredients that relieve rough skin and pimples caused by constipation. |
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Usage and dosage
| Age | Dosage per intake | Timing of intake |
|---|---|---|
| Adults (15 years and older) | 3/4 to 1 packet | 1 to 3 times a day, after meals |
| 11 years old to under 15 years old | 1/2 to 2/3 packet | 1 to 3 times a day, after meals |
| 3 years old to under 11 years old | 1/4 to 1/3 packet | 1 to 3 times a day, after meals |
| Under 3 years old | Do not take if | |
💡 Dosage advice: Take without chewing with a glass of water or lukewarm water (about 180mL).
Always start with the minimum amount for the first time, and gradually increase or decrease the dosage while monitoring your bowel movements.
Store the remaining divided packets by folding the bag's opening and take them as soon as possible.
Always start with the minimum amount for the first time, and gradually increase or decrease the dosage while monitoring your bowel movements.
Store the remaining divided packets by folding the bag's opening and take them as soon as possible.
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Dosage Steps
1
Take out the Stick
Open the Stick packaging and check the amount according to age and condition. Start with the minimum amount (3/4 packet for adults) the first time.
2
Take with a glass of water (about 180mL)
Take without chewing with water or lukewarm water. Dietary fiber absorbs water and swells, so sufficient water is essential. Too little water may reduce effectiveness.
3
Take after meals (1 to 3 times a day)
Take after meals. Can be adjusted from 1 to 3 times a day according to bowel condition.
4
Adjust the amount while monitoring bowel condition
Gradually increase or decrease the amount while checking bowel condition. Overdose may cause diarrhea or abdominal pain.
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With One Series Comparison
New With One α ★This product
Also for constipation-related skin troubles
🍑 Peach flavor
Dietary fiber + sennoside +
Sanki-rai extract (skin care)
Sanki-rai extract (skin care)
With One L
For constipation with bloating
🥛 Yogurt flavor
Dietary fiber + sennoside +
Spore-forming lactic acid bacteria that reach the intestines
Spore-forming lactic acid bacteria that reach the intestines
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Frequently Asked Questions
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What is the difference between New With One and New With One α?α contains added skin care ingredient "Sanki-rai extract." For those concerned about not only constipation but also skin troubles and acne, New With One α is recommended. The basic dietary fiber + sennoside formula is common.
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Why is it necessary to drink plenty of water?The main ingredient Plantago Ovata seed husk powder is a dietary fiber that absorbs water and swells. Taking it with sufficient water (about 180mL) allows it to swell properly in the intestines and be effective. Too little water risks swelling in the esophagus or stomach.
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From what age can it be used?Can be taken from age 3 and up. When children take it, always do so under the guidance and supervision of a guardian. Do not give to children under 3 years old.
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Which is best for constipation with bloating?For painful constipation with bloating, "With One L" is recommended. Contains spore-forming lactic acid bacteria that survive to the intestines to improve constipation while balancing the intestinal environment.
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How long does it take to see effects?Because it is based on plant ingredients, it features a gentle effect. There are individual differences, so start with the minimum amount the first time and adjust the dose while monitoring bowel movements.
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Precautions for Use and Storage
⚠ Important Precautions for Use
- This is a Designated Class 2 OTC Drug. Consult a pharmacist or registered seller before use.
- Do not give to infants under 3 years old.
- Take with a glass of water (about 180mL) or lukewarm water. Taking without enough water is dangerous.
- If you are breastfeeding, either do not take or avoid breastfeeding while taking this product.
- If you are pregnant or may be pregnant, consult a doctor or pharmacist before use.
- If symptoms do not improve or worsen, stop taking and consult a doctor or pharmacist.
- Store in a cool, dry place away from direct sunlight and out of reach of children.
- Do not take products past their expiration date.
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With One Brand Story
The plant-based laxative "With One" is a brand born with the concept of facing women's true feelings and concerns for natural-like bowel movements.
- 1955 Founded as Zeria Yakusho Research Institute in Chuo-ku, Tokyo.
- 1970 Changed company name to Zeria Pharmaceutical Co., Ltd.
- November 1987 Plant-based laxative "With One" released – born as Japan's first full-fledged plant-based laxative.
- 2000 Listed on the First Section of the Tokyo Stock Exchange (now Prime Market).
- January 2012 Improved formula version "New With One" released. Evolved to a gentler feel.
- Since 2012 Added "New With One α Peach Flavor." Contains Sanki-rai extract to address the double concerns of constipation and skin troubles.
- ~Present With One L (containing lactic acid bacteria) has also been added to the lineup, continuing to be supported as a representative brand of Japanese plant-based laxatives.
⚕ This medicine should be used after consulting a pharmacist or registered seller and carefully reading the "Precautions for Use."
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