






Smile 40 Premium THE ONE Mild
Eye drops for eye fatigue, itchiness, and redness.
For these people and situations
Product overview
Eye drops for eye fatigue, itchy eyes, and conjunctival redness. Contains vitamin A, natural-form vitamin E, and herbal medicine-derived ingredients. Contains no preservatives, with preservative action provided by unique technology.
Product features
Smile's unique technology
Preservative action is provided by Smile's unique technology.
Expiration date and storage method
Use and store this product in the same way as eye drops containing preservatives, including with regard to the expiration date and storage method.
*1 Due to mild rubbing
*2 The standards define the range of medicines established by the Ministry of Health, Labour and Welfare to streamline the approval process.
Read more about its features
One common cause of eye fatigue, blurred vision, redness, and itchiness
Contains vitamin A to repair corneal damage*1
Treat all these symptoms with one bottle!
Contains 12 active ingredients, the most in Japan (within the standards*2)
Addressing the cause × addressing the symptoms
*1 Due to mild rubbing
*2 The standards define the range of medicines established by the Ministry of Health, Labour and Welfare to streamline the approval process.
No preservatives added
Preservative action is provided by Smile's unique technology. No preservatives (such as benzalkonium chloride) are added. Use and store this product in the same way as eye drops containing preservatives, including with regard to the expiration date and storage method.
Cooling sensation level: 2
Active ingredients (per 100 mL)
| Active ingredients | Amount | Function |
|---|---|---|
| Retinol palmitate (vitamin A) | 50,000 units | A vitamin that acts directly on the cornea and supports visual function. |
| d-α-Tocopherol acetate (natural-form vitamin E) | 0.045g | A vitamin that promotes blood circulation and supplies nutrients to the eyes. |
| Pyridoxine hydrochloride (vitamin B6) | 0.01g | A vitamin that helps promote metabolism. |
| Sodium chondroitin sulfate | 0.1g | Keeps the eyes moist and protects the cornea. |
| Taurine | 1 g | Amino acids that help promote metabolism. |
| Potassium L-aspartate | 0.8g | Amino acids that help the eyes take in oxygen. |
| Neostigmine methylsulfate | 0.005g | Improves the eye's focusing function. |
| Chlorpheniramine maleate | 0.03g | Relieves uncomfortable symptoms such as itchy eyes. |
| Tetrahydrozoline hydrochloride | 0.02g | Relieves eye redness. |
| Epsilon-aminocaproic acid | 1 g | Relieves eye inflammation. |
| Berberine chloride hydrate | 0.015g | An herbal medicine-derived ingredient with antibacterial and anti-inflammatory effects. |
| Dipotassium glycyrrhizinate | 0.25g | An herbal medicine-derived ingredient with anti-inflammatory effects. |
Contains the following additives: boric acid, trometamol, sodium edetate, BHT, propylene glycol, povidone, hypromellose, polyoxyethylene polyoxypropylene glycol, l-menthol, dl-camphor, d-borneol, and pH adjuster.
Indications and Effects
Dosage and Administration
Consultation
- 1. Consult a doctor, pharmacist, or registered salesperson before use if:
- (1) People receiving medical treatment.
- (2) People who have had allergic reactions to medicines or other substances.
- (3) People with severe eye pain.
- (4) People diagnosed with glaucoma.
- 2. If any of the following symptoms occur after use, they may be side effects. Stop using this product immediately and consult a doctor, pharmacist, or registered salesperson with this document.
Affected area Symptoms Skin Rash, redness, itching Eyes Redness, itching, swelling, stinging pain - 3. Stop using this product and consult a doctor, pharmacist, or registered salesperson with this document if:
- (1) If blurred vision does not improve.
- (2) If symptoms do not improve after 5–6 days of use.
- This product contains a high-viscosity ingredient. Your vision may be temporarily blurred after use, so take care.
- (1) Store tightly closed in a cool place away from direct sunlight.
- To maintain quality, do not leave in hot places (40°C or above), such as inside a car or near a heater.
- (2) Keep out of reach of children.
- (3) Do not transfer to another container (this may cause misuse or affect quality).
- (4) Do not share with others.
- (5) Do not use this product after its expiration date (printed on the bottom of the outer box). Even if it is within the expiration date, use it as soon as possible after opening.
- (6) If you instill the drops with the bottle on its side, or depending on storage conditions, crystals of the ingredients may adhere to the tip or cap.
- If this happens, gently wipe it off with clean gauze before use.
- (7) The Liquid is yellow because it contains ingredients derived from crude drugs. It may stain clothing and other items, so take care to avoid contact.
- (8) An oxygen absorber is included to maintain quality.
- After opening the clear film, discard the oxygen absorber.
- ◇To protect the natural environment, no carry bag is included.













































































