Sante Medical
Guard & Repair
Due to dryness and corneal damage
For stinging and eye inflammation*.
*Ocular inflammation caused by ultraviolet and other light rays (such as snow blindness)
For these situations
Due to dryness or Contact lens wear
For those whose eyes are under strain
Discomfort after removing Contact lenses
Eyes feel dry and rough
Eye surface stings or prickles
*Discomfort when wearing hard Contact lensesFrequently rubs eyes
Exposed to ultraviolet rays
Product features
Promotes repair of damaged tissue,
Suppresses inflammation (such as snow blindness)
Protects and moisturizes the cornea
Improves eye fatigue caused by dryness and more
Promotes tissue metabolism
Improves eye fatigue
OVERVIEW Product Overview
Sante Medical Guard & Repair is an ophthalmic drug (Class 2 OTC Drug) newly released by Santen Pharmaceutical in November 2025. Modern eyes are subjected daily to damage on the corneal surface due to overuse, rubbing, Contact lens wear, ultraviolet rays, and more. If such corneal damage is left untreated, it can worsen eye inflammation or cause eye diseases.
This product contains zinc sulfate hydrate, a corneal repair & barrier function enhancing ingredient, and chondroitin sulfate ester sodium, a corneal protection and moisturizing ingredient, among 6 ingredients formulated at the maximum concentration within approval standards, totaling 10 active ingredients. It repairs and protects corneal damage, effectively addressing eye inflammation (such as snow blindness) and preventing eye diseases and other eye troubles.
INGREDIENTS Active ingredients, amounts, and functions
| Ingredient name | Amount | Function |
|---|---|---|
| Zinc sulfate hydratemaximum concentrationcorneal repair | 0.25% | Promotes repair of damaged tissue and suppresses inflammation. |
| Chondroitin sulfate ester sodiummaximum concentration | 0.5% | Protects the cornea and provides moisture to the eyes by preventing tear evaporation. |
| Taurine | 0.5% | Activates tissue metabolism in the eyes. |
| Vitamin B6 (pyridoxine hydrochloride)maximum concentration | 0.1% | Activates tissue metabolism in the eyes. |
| Panthenol | 0.05% | Activates tissue metabolism in the eyes. |
| L-aspartic acid potassium salt | 0.5% | Enhances tissue respiration in the eyes. |
| Neostigmine methyl sulfatemaximum concentration | 0.005% | Improves focusing function, relieving eye fatigue and more. |
| Chlorpheniramine maleatemaximum concentration | 0.03% | Suppresses the action of histamine, reducing eye inflammation and itching. |
| Epsilon-Aminocaproic acid | 1.0% | Suppresses the production of substances that cause inflammation. |
| Tetrahydrozoline hydrochloridemaximum concentration | 0.05% | Suppresses redness of the conjunctiva (the white part of the eye). |
*Maximum concentration = maximum concentration formulation based on the standards for general ophthalmic drug manufacturing and marketing approval (6 ingredients)
EFFICACY Indications and Effects
Eye inflammation caused by ultraviolet or other rays (snow blindness, etc.), blepharitis (eyelid inflammation), prevention of eye diseases (after swimming, when dust or sweat gets into the eyes, etc.), eye fatigue, eye itching, eye blurriness (when there is a lot of eye discharge), conjunctival redness, discomfort when wearing hard Contact lenses
DOSAGE Dosage and Administration
Instill the following amount 5 to 6 times a day.
| Age | Amount per instillation | Number of times per day |
|---|---|---|
| Adults and children (7 years and older) | 1 to 3 drops | 5 to 6 times |
| Under 7 years old | × Do not use | — |
- Strictly follow the dosage and administration instructions.
- When used by children, use under the guidance and supervision of a guardian.
- When instilling, avoid touching the tip of the container to eyelids, eyelashes, or eyes (to prevent contamination).
- For ophthalmic use only.
COMPARISON Sante Medical Series Comparison Table

| Comparison items | Medical Guard & Repair (This product) |
Medical 12 | Medical Active |
|---|---|---|---|
| Main concerns & features | Corneal damage repair, inflammation, and stinging | Eye fatigue and redness | Eye fatigue, blurriness, and dryness due to aging |
| Number of active ingredients | 10 types | ★ 12 types | 9 types |
| Maximum concentration ingredient count | ★ 6 ingredients | 4 ingredients | 5 ingredients |
| Zinc sulfate hydrate (Corneal repair & barrier) |
✔ 0.25% | 0.05% | - |
| Vitamin B12 (Ciliary muscle & eye fatigue) |
- | ✔ 0.02% | - |
| Vitamin A (Tear secretion & corneal protection) |
- | - | ✔ 50,000 units |
| Vitamin E (Blood flow improvement) |
- | - | ✔ 0.05% |
| Neostigmine (Focus adjustment) |
✔ | ✔ | ✔ |
| Chondroitin (Moisturizing & corneal protection) |
✔ | ✔ | ✔ |
| Epsilon-Aminocaproic acid (Anti-inflammatory) |
✔ 1.0% | ✔ 1.0% | ✔ 1.0% |
| Glycyrrhizic acid (Anti-inflammatory) |
- | ✔ 0.1% | - |
| Redness relief ingredient (Tetrahydrozoline) |
✔ 0.05% | 0.03% | 0.01% |
| Panthenol (Tissue metabolism) |
✔ 0.05% | ✔ 0.05% | - |
| For people like this | Eyes are easily damaged by Contact lenses, UV rays, and dryness. Want to focus on corneal repair. | Eyes are overused with PC and smartphones. Want to thoroughly care for redness and eye fatigue. | Concerned about dry eyes, blurriness, and fatigue due to aging. |
* Ingredient content is based on the official Santen Pharmaceutical package inserts for each product. Please check the latest product labeling at the time of purchase.
CAUTION Precautions for Use / Storage Precautions
- Do not use if you have had allergic reactions to this product or its ingredients.
- Do not use on the following areas: around the eyes or inside the mouth
- Do not use while wearing soft Contact lenses.
- People receiving treatment from a doctor or dentist
- People who have had allergic reactions to medicines
- People with the following symptoms: severe eye pain
- People diagnosed with: glaucoma
- If allergic symptoms such as redness, itching, or swelling appear after instilling, stop use immediately and consult a doctor, pharmacist, or registered seller.
- If eye blurriness does not improve, consult a doctor, pharmacist, or registered seller.
- Store tightly closed in a cool place away from direct sunlight.
- Keep out of reach of children.
- Do not transfer to other containers (this may cause misuse or change the quality).
- Do not use products past the expiration date.
- Use within 3 months after opening as a guideline.
- Close the cap immediately after instilling the eye drops.
* For product details and the latest information, please be sure to check the package insert included with the product.
* "Corneal Repair & Barrier Function Improvement Ingredients": Eri Matsuura et al., Medicine and Pharmacy 82(5): P241, 2025
【Class 2 OTC Drug】Please read the "Precautions for Use" carefully before using this medicine.














































































