






Smile 40 Premium THE ONE Cool
Eye drops for eye fatigue, blurred vision, redness, and itching
For whom / when
Product overview
Eye drops for eye fatigue, blurred vision (such as when there is a lot of eye discharge), conjunctival redness, itchy eyes, and other symptoms. Vitamin A acts directly on the cornea and supports visual function. Sodium chondroitin sulfate keeps eyes moist and protects the cornea.
No preservatives are added. Do not use while wearing soft contact lenses.
Product features
Smile's proprietary technology
Smile uses its proprietary technology to provide a preservative effect.
Expiration date and storage
The product can be used and stored in the same way as eye drops containing preservatives, including with regard to expiration date and storage.
*1 Caused by mild rubbing
*2 Standards refer to the scope of medicines established by the Ministry of Health, Labour and Welfare to streamline the approval process.
Read more about its features
One common cause of eye fatigue, blurred vision, redness, and itching
Contains vitamin A to repair corneal damage*1
Treat all these symptoms with just one bottle!
Contains 12 active ingredients, the most in Japan (within the standards*2)
Cause-focused approach × symptom-focused approach
*1 Caused by mild rubbing
*2 Standards refer to the scope of medicines established by the Ministry of Health, Labour and Welfare to streamline the approval process.
No preservatives added
Smile uses its proprietary technology to provide a preservative effect. No preservatives (such as benzalkonium chloride) are added. The product can be used and stored in the same way as eye drops containing preservatives, including with regard to expiration date and storage.
Cooling sensation level: 4
Active ingredients (per 100 mL)
| Active ingredient | Content | Function |
|---|---|---|
| Retinol palmitate (vitamin A) | 50,000 units | A vitamin that acts directly on the cornea and supports visual function. |
| d-α-Tocopherol acetate (natural vitamin E) | 0.045g | A vitamin that promotes blood circulation and supplies nutrients to the eyes. |
| Pyridoxine hydrochloride (vitamin B6) | 0.01g | A vitamin that helps promote metabolism. |
| Sodium chondroitin sulfate | 0.1g | Keeps eyes moist and protects the cornea. |
| Taurine | 1g | Amino acids that help promote metabolism. |
| L-potassium aspartate | 0.8g | Amino acids that help the eyes take in oxygen. |
| Neostigmine methyl sulfate | 0.005g | Improves the eye's focusing function. |
| Chlorpheniramine maleate | 0.03g | Relieves discomfort such as itchy eyes. |
| Tetrahydrozoline hydrochloride | 0.02g | Relieves eye redness. |
| Epsilon-aminocaproic acid | 1g | Relieves eye inflammation. |
| Berberine chloride hydrate | 0.015g | An herbal medicine-derived ingredient with antibacterial and anti-inflammatory effects. |
| Dipotassium glycyrrhizinate | 0.25g | An herbal medicine-derived ingredient with anti-inflammatory effects. |
Contains the following additives: boric acid, trometamol, sodium edetate, BHT, propylene glycol, povidone, hypromellose, polyoxyethylene polyoxypropylene glycol, l-menthol, d-borneol, and pH adjuster.
Indications
Directions and Dosage
Consultation
- 1. The following people should consult a doctor, pharmacist, or registered pharmacist before use.
- (1)People receiving medical treatment.
- (2)People who have had allergic symptoms caused by medicines or other substances.
- (3)People with the following symptom: severe eye pain.
- (4)People diagnosed with glaucoma.
- 2. If any of the following symptoms occur after use, they may be side effects. Stop use immediately and consult a doctor, pharmacist, or registered pharmacist, bringing this document with you.
Affected area Symptoms Skin Rash, redness, itching Eyes Redness, itching, swelling, stinging pain - 3. Stop use in the following cases and consult a doctor, pharmacist, or registered pharmacist, bringing this document with you.
- (1)If blurred vision does not improve.
- (2)If symptoms do not improve after 5–6 days of use.
- Contains ingredients that increase viscosity. Vision may be temporarily blurred after use, so take care.
- (1)Store tightly closed in a cool place away from direct sunlight.
- To maintain quality, do not leave the product in hot places (40°C or above), such as inside a car or near a heater.
- (2)Keep out of reach of children.
- (3)Do not transfer the product to another container (this may cause misuse or affect its quality).
- (4)Do not share with others.
- (5)Do not use the product after its expiration date (printed on the bottom of the outer box). Even before the expiration date, use it as soon as possible after opening.
- (6)If you instill the drops while holding the container sideways, or depending on storage conditions, crystals of the ingredients may form on the tip or cap.
- If this happens, gently wipe it off with clean gauze before use.
- (7)The Liquid is yellow because it contains ingredients derived from crude drugs. It may stain clothing and other items, so take care to avoid spills.
- (8)An oxygen absorber is included to maintain quality.
- After opening the clear film, discard the oxygen absorber.
- ◇To protect the natural environment, no carry bag is included.













































































